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KMID : 0361019960390010081
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Korean Journal of Otolaryngology - Head and Neck Surgery
1996 Volume.39 No. 1 p.81 ~ p.89
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Amplification and Overxpression of Her-2/neu in Salivary Gland Tumor
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Abstract
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The Her-2/neu oncogene demonstrated a close relationship to the human epidermal growth factor receptor and it was first identified as a dominant as a dominant transforming gene in chemically induced adrenal neuroblastomas of neonatal mice. It has
been
reported that patients with breast cancer showing such overexpression and amplification have a poorer prognosis than those without overexpression and amplification. There are few reliable prognostic markers of biological aggressiveness for head
and
neck
tumors including salivary gland tumors.
Eight cases of benign salivary gland tumors and 18 cases of malignant gland tumors were analyzed for a molecular genetic alteration, Her-2/neu gene amplification by FISH (fluorescence in situ hybridization) and overexpression by
immunohistochemistry
results were compaired with clinically important risk factors.
@ES The results were as follows:
@EN 1) Overexpression was observed in 3 of 8(38%) benign salivary gland tumors and in 13 of 18(72%) Inalignant salivary gland tumors. But this difference was not statistically significant(p>0.05).
2) Gene amplification was observed in 0 of 8(0%) benign salivary gland tumors and in 10 of 18(56%) malignant salivary tumors. This difference was statistically significant(p=0.007).
3) Gene amplification and overexpression in malignant salivary gland tumors were not correlated with age, gender, tumor isze and L.N. metastasis(p>0.05), but overexpression was found more frequently in high grade malignant salivary gland
tumors(p=0.011).
4) In conclusion, overexpression and gene amplification of Her-w/neu in the salivary gland tumors are not enough for the prognosticator. (Korean J Otolaryngol 39 : 1, 1996)
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